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T Shimotake Selected Research

total intestinal Aganglionosis

11/2001Relationship between the type of RET/GDNF/NTN or SOX10 gene mutations and long-term results after surgery for total colonic aganglionosis with small bowel involvement.
4/2001A homozygous missense mutation in the tyrosine E kinase domain of the RET proto-oncogene in an infant with total intestinal aganglionosis.

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T Shimotake Research Topics

Disease

4Hirschsprung Disease (Hirschsprung's Disease)
11/2001 - 08/2000
2total intestinal Aganglionosis
11/2001 - 04/2001
2Anorectal Malformations
02/2001 - 08/2000
1Umbilical Hernia (Omphalocele)
04/2006
1Thyroid Neoplasms (Thyroid Cancer)
06/2001
1Hereditary renal agenesis
04/2001
1Adenocarcinoma
02/2001
1Choledochal Cyst (Choledochal Cysts)
02/2001
1Fistula
08/2000
1Cleft Palate (Palate, Cleft)
08/2000

Drug/Important Bio-Agent (IBA)

3Glial Cell Line-Derived Neurotrophic Factor (GDNF)IBA
11/2001 - 08/2000
1NeurturinIBA
04/2001
1LigandsIBA
04/2001
1Phosphotransferases (Kinase)IBA
04/2001
1Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
04/2001
1Tyrosine (L-Tyrosine)FDA Link
04/2001
1Tretinoin (Retinoic Acid)FDA LinkGeneric
02/2001
1Retinoic Acid Receptors (Retinoic Acid Receptor)IBA
02/2001
1AmylasesFDA Link
02/2001
1EtretinateFDA Link
08/2000
1Vitamin A (Retinol)FDA LinkGeneric
08/2000

Therapy/Procedure

1Colostomy
04/2006
1Myotomy
11/2001
1Thyroidectomy
06/2001